抗衰肽生物调节剂可诱导染色质重新激活。

Anti-aging peptide bioregulators induce reactivation of chromatin.

作者信息

Lezhava T, Monaselidze J, Kadotani T, Dvalishvili N, Buadze T

机构信息

Tbilisi State University.

出版信息

Georgian Med News. 2006 Apr(133):111-5.

PMID:16705247

Abstract

The effect of synthetic peptide bioregulators (Epitalon, Livagen and Vilon) on structural and facultative heterochromatin of cultivated lymphocytes have been studied among old (75-88yr.) people. The data obtained indicate that epitalon, livagen and vilon: 1) activate synthetic processes, caused by reactivation of ribosomal genes as a result of deheterochromatinization (decondensation) of nucleolus organizer regions; 2) induce unrolling (deheterochromatinization) of total heterochromatin; 3) release genes repressed by heterochromatinization (condensation) of euchromatic regions forming facultative heterochromatin; 4) epitalon and livagen induce deheterochromatinization (decondensation) of pericentromeric structural heterochromatin of the chromosomes1 and 9. However, vilon does not induce deheterochromatinization of pericentromeric structural heterochromatin. These results indicate that peptide bioregulators Epitalon, Livagen and Vilon cause activation (deheterochromatinization) of chromatin in lymphocytes of old individuals.

摘要

在老年人（75 - 88岁）中研究了合成肽生物调节剂（埃匹他隆、利瓦金和维隆）对培养淋巴细胞的结构型和兼性异染色质的影响。所获得的数据表明，埃匹他隆、利瓦金和维隆：1）由于核仁组织区的去异染色质化（解聚）而激活核糖体基因的再激活所引发的合成过程；2）诱导总异染色质的解旋（去异染色质化）；3）释放因常染色质区异染色质化（凝聚）形成兼性异染色质而被抑制的基因；4）埃匹他隆和利瓦金诱导染色体1和9的着丝粒周围结构异染色质的去异染色质化（解聚）。然而，维隆不诱导着丝粒周围结构异染色质的去异染色质化。这些结果表明，肽生物调节剂埃匹他隆、利瓦金和维隆可导致老年个体淋巴细胞中染色质的激活（去异染色质化）。