Mittermayer C, Blaicher W, Brugger P C, Bernaschek G, Lee A
Department of Neonatology and Intensive Care, University Hospital of Vienna, Austria.
Ultraschall Med. 2004 Apr;25(2):120-5. doi: 10.1055/s-2004-813102.
To examine whether three-dimensional ultrasound (3D US) is an accurate diagnostic method of clinical use in the ability to define the location and extent of facial clefting prenatally, compared to two-dimensional ultrasound (2D US).
18 foetuses suspected or diagnosed to suffer from a facial cleft by 2D US were examined with a targeted 3D US. 2D US and 3D US results were compared with postnatal outcome.
Comparison of the number of foetuses with a cleft lip + primary palate diagnosed correctly with 2D US with the results of adjunctive 3D US (true positive + true negative) showed that adjunctive 3D US correctly diagnosed more cleft lips (100 %; 15/15 foetuses vs. 66 %; 12/18 foetuses) and more cleft primary palates (100 %; 12/12 foetuses vs. 58 %; 7/12 foetuses).
Interactive review of standardised 3D multiplanar images allows to systematically evaluate lip defects and abnormalities of the maxillary tooth-bearing alveolar ridge. The accuracy of adjunctive 3D ultrasound is superior to 2D ultrasound alone for extensive prenatal diagnosis of cleft lip with or without cleft primary palate.
为了研究与二维超声（2D US）相比，三维超声（3D US）在产前确定面部裂隙位置和范围方面是否是一种准确的临床诊断方法。
对18例经二维超声怀疑或诊断为面部裂隙的胎儿进行针对性三维超声检查。将二维超声和三维超声的结果与产后结果进行比较。
将二维超声正确诊断的唇裂+原发性腭裂胎儿数量与辅助三维超声的结果（真阳性+真阴性）进行比较，结果显示辅助三维超声正确诊断出更多的唇裂（100%；15/15例胎儿对66%；12/18例胎儿）和更多的原发性腭裂（100%；12/12例胎儿对58%；7/12例胎儿）。
对标准化三维多平面图像进行交互式回顾，有助于系统地评估唇裂缺陷和上颌含牙牙槽嵴的异常情况。对于伴有或不伴有原发性腭裂的唇裂的广泛产前诊断，辅助三维超声的准确性优于单纯二维超声。
