Wang L M, Leung K Y, Tang Mary
Guangdong Women and Children Hospital, Ultrasound, China.
Prenat Diagn. 2007 Aug;27(8):722-9. doi: 10.1002/pd.1766.
To determine the prenatal diagnostic accuracy of two-dimensional ultrasound (2DUS) alone versus 2DUS in conjunction with three-dimensional ultrasonography (3DUS) including orthogonal display (OGD) and three-dimensional extended Imaging for cleft lip and primary palate.
Fetuses being suspected of having a facial cleft by previous ultrasound examination or family history were examined sequentially with 2DUS and then 3DUS.
Of a total of 30 infants, 22 had cleft lip and nine also had cleft palate at birth. The use of 2DUS with or without 3DUS correctly identified all cases of cleft lips prenatally. However, the use of 2DUS in conjunction with 3DUS correctly identified more cleft primary palate than 2DUS alone (88.9% vs 22.2%, P < 0.01). Cleft primary palate was well demonstrated in both the multi-slice view (MSV) and OGD modes. In one case, a cleft palate was shown in the MSV mode but not in the Oblique view (OBV) mode. All the unaffected fetuses were reported as no cleft palate with the use of MSV mode.
Combined approach of 2DUS and 3DUS with both OGD and MSV modes significantly improved the prenatal detection rate for a cleft palate compared with 2DUS alone (88.9% vs 22.2%) without decreasing the specificity.
确定单纯二维超声（2DUS）与二维超声联合三维超声（3DUS，包括正交显示（OGD）和三维扩展成像）用于唇裂和原发腭裂产前诊断的准确性。
对因先前超声检查或家族史怀疑有面部裂隙的胎儿依次进行二维超声和三维超声检查。
总共30例婴儿中，22例出生时患有唇裂，9例还患有腭裂。使用二维超声（无论有无三维超声）在产前正确识别了所有唇裂病例。然而，二维超声联合三维超声比单纯二维超声能更准确地识别更多的原发腭裂病例（88.9%对22.2%，P<0.01）。在多平面视图（MSV）和正交显示（OGD）模式下，原发腭裂均显示良好。有1例，在多平面视图模式下显示有腭裂，但在斜视图（OBV）模式下未显示。使用多平面视图模式时，所有未受影响的胎儿均报告为无腭裂。
与单纯二维超声相比，二维超声和三维超声联合使用OGD和MSV模式显著提高了腭裂的产前检出率（88.9%对22.2%），且不降低特异性。
