免疫组织化学检测的HER-2/neu（c-erbB-2）与胰腺癌组织学分期及神经周围侵犯的相关性
Correlation of immunohistochemically detected HER-2/neu (c-erbB-2) with histological stage and perineural invasion in pancreatic cancer.
作者信息
Tamiolakis D, Venizelos I, Simopoulos C, Kotini A, Jivannakis T, Papadopoulos N
机构信息
Department of Cytology, General Hospital of Chania, Crete, Greece.
出版信息
Hepatogastroenterology. 2004 Mar-Apr;51(56):334-7.
BACKGROUND/AIMS: HER-2/neu (c-erbB-2) oncoprotein is a transmembrane glycoprotein and may function as a growth factor being involved in the regulation of cell growth and cell transformation. c-erbB-2 was correlated with established outcome factors in pancreatic cancer.
METHODOLOGY
We performed an analysis of 100 patients with pancreatic cancer using an immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue samples in order to determine HER-2/neu oncoprotein expression along with stage and perineural involvement.
RESULTS
HER-2/neu oncoprotein was expressed in the tumors of 21 patients (21%).
CONCLUSIONS
Histologic stage, and perineural invasion did not correlate with HER-2/neu oncoprotein.
背景/目的：HER-2/neu（c-erbB-2）癌蛋白是一种跨膜糖蛋白，可能作为一种生长因子参与细胞生长和细胞转化的调节。c-erbB-2与胰腺癌已确定的预后因素相关。
方法
我们采用免疫过氧化物酶技术，对100例胰腺癌患者福尔马林固定、石蜡包埋的组织样本进行分析，以确定HER-2/neu癌蛋白表达情况以及分期和神经周围侵犯情况。
结果
21例患者（21%）的肿瘤中表达了HER-2/neu癌蛋白。
结论
组织学分期和神经周围侵犯与HER-2/neu癌蛋白不相关。
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