Mansouritorgabeh H, Rezaieyazdi Z, Pourfathollah A A, Rezai J, Esamaili H
Experimental Hematology and Blood Banking Group, Medical Sciences School, Tarbiat Modarres University, Tehran, Iran.
Haemophilia. 2004 May;10(3):271-5. doi: 10.1111/j.1365-2516.2004.00890.x.
Of the six types of dual coagulation factors deficiency, combined factors V and VIII are the most common type, a few cases of this disease have been reported in different populations. This accounts for the relatively low number of cases reported so far. Our report, which included 19 patients, is the second largest group that has been reported from one centre in north-eastern Iran. The most frequent spontaneous bleeding symptoms were epistaxis and haemarthrosis, and the most frequent traumatic bleeding symptoms were bleeding after dental extraction and bleeding after cutting any part of the body. It seemed that dual coagulation FV and FVIII deficiency is as severe as single coagulation factor (V or VIII) deficiency.
在六种类型的双凝血因子缺乏症中，凝血因子V和VIII联合缺乏是最常见的类型，不同人群中均有少数该病病例的报道。这导致了目前已报道病例数量相对较少。我们的报告纳入了19例患者，是伊朗东北部一个中心所报道的第二大病例组。最常见的自发性出血症状是鼻出血和关节积血，最常见的创伤性出血症状是拔牙后出血和身体任何部位切割后出血。看来凝血因子V和VIII联合缺乏与单一凝血因子（V或VIII）缺乏一样严重。
