Lin Z, Forster J, Sarosiek I, McCallum R W
Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Neurogastroenterol Motil. 2004 Apr;16(2):205-12. doi: 10.1111/j.1365-2982.2004.00503.x.
The aim of this study was to investigate the effect of gastric electrical stimulation (GES) on gastric myoelectric activity (GMA) and to identify possible mechanisms that could help explain how high-frequency GES is effective in treating nausea and vomiting associated with gastroparesis. Fifteen gastroparetic patients who received high-frequency GES were enrolled. Two pairs of temporary pacing wires were implanted on the serosa of the stomach along the greater curvature during surgery for placement of the permanent stimulation device. Two-channel serosal recordings of GMA before and during GES were measured. A gastric emptying test and severity of nausea and vomiting were assessed at baseline and at 3 months of GES. Power spectral and cross correlation analyses revealed that impaired propagation of slow waves (50%), tachygastria (30%) and abnormal myoelectric responses to a meal (50%) were the main abnormalities observed at baseline. GES with a high frequency significantly enhanced the slow wave amplitude and propagation velocity, and resulted in a significant improvement in nausea and vomiting but did not entrain the gastric slow wave or improve gastric emptying after 3 months of GES.
本研究的目的是探讨胃电刺激（GES）对胃肌电活动（GMA）的影响，并确定可能有助于解释高频GES如何有效治疗与胃轻瘫相关的恶心和呕吐的机制。招募了15名接受高频GES的胃轻瘫患者。在植入永久性刺激装置的手术过程中，沿着胃大弯在胃浆膜上植入两对临时起搏电极。测量了GES前和GES期间GMA的双通道浆膜记录。在基线和GES治疗3个月时评估胃排空试验以及恶心和呕吐的严重程度。功率谱和互相关分析显示，慢波传播受损（50%）、快速胃动（30%）和对进食的异常肌电反应（50%）是基线时观察到的主要异常情况。高频GES显著提高了慢波幅度和传播速度，并使恶心和呕吐得到显著改善，但在GES治疗3个月后并未夹带胃慢波或改善胃排空。
