Chen J D Z, Xu X, Zhang J, Abo M, Lin X, McCallum R W, Ross B
VA Research Foundation, VA Medical Center, Oklahoma City, OK, USA.
Neurogastroenterol Motil. 2005 Dec;17(6):878-82. doi: 10.1111/j.1365-2982.2005.00688.x.
Gastric electrical stimulation (GES) using single channel has been under investigation for its therapeutic potential for gastroparesis. The aim of this study was to study the efficacy and efficiency of multi-channel GES in accelerating gastric emptying in dogs. The study was performed in eight dogs, and gastric emptying of liquid was assessed in three randomized sessions of control, one-channel GES and four-channel GES. It was found that (i) GES of both one-channel and four-channel was able to completely entrain the slow waves in the entire stomach. However, the stimulation energy required by four-channel GES was only 1% of that required by one-channel GES. (ii) Four-channel, but not one-channel, GES significantly and substantially accelerated gastric emptying. An increase of 121.0 and 93.9% was noted with four-channel GES at 30 and 60 min after the meal, respectively. It was concluded that four-channel GES is substantially more efficient and effective than conventional single-channel GES in improving gastric emptying. It is worthy to explore its therapeutic potential for gastroparesis in clinical settings.
单通道胃电刺激（GES）治疗胃轻瘫的潜在疗效一直在研究中。本研究旨在探讨多通道GES在加速犬胃排空方面的疗效和效率。该研究在8只犬身上进行，在对照、单通道GES和四通道GES的三个随机阶段评估液体的胃排空情况。结果发现：（i）单通道和四通道GES均能完全带动整个胃的慢波。然而，四通道GES所需的刺激能量仅为单通道GES的1%。（ii）四通道而非单通道GES能显著且大幅加速胃排空。餐后30分钟和60分钟时，四通道GES分别使胃排空增加了121.0%和93.9%。结论是，在改善胃排空方面，四通道GES比传统单通道GES更高效、更有效。值得在临床环境中探索其治疗胃轻瘫的潜在疗效。
