Meir Karen S, Leitersdorf Eran
Department of Pathology, Hadassah University Hospital, Kiryat Hadassah, Jerusalem, Israel.
Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1006-14. doi: 10.1161/01.ATV.0000128849.12617.f4. Epub 2004 Apr 15.
Arguably the most critical advancement in the elucidation of factors affecting atherogenesis has been the development of mouse models of atherosclerosis. Among available models, the apolipoprotein E-deficient (apoE-/-) mouse is particularly popular because of its propensity to spontaneously develop atherosclerotic lesions on a standard chow diet. A Medline search reveals over 645 articles dedicated to studies using this reliable and convenient "super" animal model since its inception (Piedrahita JA et al, Proc Natl Acad Sci U S A 1992;89:4471-4475; Plump AS et al, Cell 1992;71:343-353) with a more or less steady increase from year to year. This review will examine our present understanding of the pathology and progression of plaques in this animal and highlight some of the nutritional, pharmacological, and genetic studies that have enhanced this understanding.
可以说，在阐明影响动脉粥样硬化形成的因素方面，最关键的进展是动脉粥样硬化小鼠模型的开发。在现有的模型中，载脂蛋白E缺陷（apoE-/-）小鼠特别受欢迎，因为它在标准普通饮食条件下容易自发形成动脉粥样硬化病变。自该模型建立以来，医学在线数据库（Medline）搜索显示，有超过645篇文章致力于使用这种可靠且便捷的“超级”动物模型进行研究（皮耶德雷塔·J·A等人，《美国国家科学院院刊》1992年；89:4471 - 4475；普伦普·A·S等人，《细胞》1992年；71:343 - 353），且每年的文章数量或多或少都在稳步增加。本综述将审视我们目前对该动物体内斑块病理及进展的理解，并着重介绍一些增强了这种理解的营养、药理学和遗传学研究。
