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[牛奶蛋白诱导的肺含铁血黄素沉着症:1例临床病例讨论]

[Pulmonary hemosiderosis induced by cow's milk proteins: a discussion of a clinical case].

作者信息

Fossati G, Perri M, Careddu G, Mirra N, Carnelli V

机构信息

Istituto di Clinica Pediatrica 1a, Università degli Studi di Milano, Cattedra di Ematologia Pediatrica, Italia.

出版信息

Pediatr Med Chir. 1992 Mar-Apr;14(2):203-7.

PMID:1508757
Abstract

Pulmonary hemosiderosis (PH), a rare pathology, usually occurring during infancy and childhood, is characterized by numerous and repeated intra-alveolar bleedings, interstitial iron build-up with consequent progressive fibrosis and severe anemia. PH can be basically divided into 3 different categories: Primitive or idiopathic, involving a primitive deficit of antioxidizing enzymes in the erythrocytes in genetically predisposed subjects; Secondary, subsequent to chronic pneumopathy or cardiopathy; Associated with various pathologies including collagenopathies, glomerulonephritis, myocardiopathies, diabetes, steatorrhea, tireotossicosis. A particular type of Pulmonary Hemosiderosis, associated with allergy to cow's milk, has been described for the first time by Heiner. We present in this paper our personal experience of a young patient suffering from pulmonary hemosiderosis induced by cow's milk protein.

摘要

肺含铁血黄素沉着症(PH)是一种罕见的病症,通常发生在婴儿期和儿童期,其特征是肺泡反复大量出血、间质铁沉积,进而导致进行性纤维化和严重贫血。PH基本上可分为3种不同类型:原发性或特发性,涉及遗传易感性个体红细胞中抗氧化酶的原发性缺陷;继发性,继发于慢性肺病或心脏病;与多种病症相关,包括胶原病、肾小球肾炎、心肌病、糖尿病、脂肪泻、甲状腺毒症。一种与牛奶过敏相关的特殊类型的肺含铁血黄素沉着症首次由海纳描述。本文介绍了我们对一名因牛奶蛋白诱发肺含铁血黄素沉着症的年轻患者的个人诊疗经验。

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