Sakiyan Iffet, Loğoğlu Elif, Arslan Seza, Sari Nurşen, Sakiyan Nazmiye
Ankara University, Science Faculty, Department of Chemistry, 06100 Tandogan, Ankara, Turkey.
Biometals. 2004 Apr;17(2):115-20. doi: 10.1023/b:biom.0000018380.34793.df.
The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehyde with glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese(III) complexes of these bases were investigated. Structures of the Schiff bases were proven by 1H-NMR. In vitro activities against some Gram-positive (Staphylococcus aureus and Bacillus polymyxa) and Gram-negative (Escherichia coli) bacteria and the fungus Candida albicans were determined. The antimicrobial activities tended to decrease with the increasing size of the amino acid residues.
研究了由2-羟基-1-萘甲醛与甘氨酸、L-丙氨酸、L-苯丙氨酸、L-组氨酸、L-色氨酸反应得到的五种不同氨基酸席夫碱及其锰(III)配合物的体外抗菌和抗真菌活性。通过1H-NMR证实了席夫碱的结构。测定了对一些革兰氏阳性菌（金黄色葡萄球菌和多粘芽孢杆菌）、革兰氏阴性菌（大肠杆菌）以及白色念珠菌的体外活性。抗菌活性倾向于随着氨基酸残基尺寸的增加而降低。
