Byers M R
Department of Anesthesiology, University of Washington, Seattle.
Proc Finn Dent Soc. 1992;88 Suppl 1:499-506.
A brief review of the normal sensory innervation of teeth is presented, especially concerning the fibers that are immunoreactive (IR) for calcitonin gene-related peptide (CGRP). Numerous CGRP-IR fibers innervate coronal dentin at sites populated by primary odontoblasts and associated pulp cells that synthesize nerve growth factor (NGF). If the primary odontoblasts and adjacent pulp cells are lost as a consequence of injury, CGRP-IR dentinal innervation is greatly reduced. The responses of CGRP-IR nerve fibers to pulpal injury are reviewed. Those reactions show that pulpal sensory nerve fibers can alter the size, shape and immunoreactivity of their terminal branches in response to different stages of inflammation and healing.
本文简要回顾了牙齿的正常感觉神经支配，特别是关于对降钙素基因相关肽（CGRP）具有免疫反应性（IR）的纤维。大量CGRP免疫反应性纤维支配着由初级成牙本质细胞和合成神经生长因子（NGF）的相关牙髓细胞占据的冠状牙本质部位。如果初级成牙本质细胞和相邻的牙髓细胞因损伤而丢失，CGRP免疫反应性牙本质神经支配会大大减少。本文还回顾了CGRP免疫反应性神经纤维对牙髓损伤的反应。这些反应表明，牙髓感觉神经纤维可以根据炎症和愈合的不同阶段改变其终末分支的大小、形状和免疫反应性。
