Närhi M
Proc Finn Dent Soc. 1989;85(4-5):389-93.
The function of intradental sensory receptors is strongly affected by activation of the sympathetic nerves. This effect is most probably indirect and due to changes in pulpal blood flow. Also, in inflamed teeth the sensitivity changes of pulp nerves seem to be closely related to changes in the blood flow. Such inflammatory mediators as histamine, bradykinin and serotonin affect the sensitivity of intradental receptors in pulpal inflammation. In addition, many neuropeptides, for example substance P (SP) and calcitonin gene-related peptide (CGRP), seem to be involved and may interact with histamine or bradykinin. Recent studies indicate that intradental nerves with their neuropeptides may play a significant role in the inflammatory and defence reactions of the dental pulp.
牙髓内感觉受体的功能受到交感神经激活的强烈影响。这种影响很可能是间接的，并且是由于牙髓血流的变化所致。此外，在发炎的牙齿中，牙髓神经的敏感性变化似乎与血流变化密切相关。诸如组胺、缓激肽和5-羟色胺等炎症介质在牙髓炎症中会影响牙髓内受体的敏感性。此外，许多神经肽，例如P物质（SP）和降钙素基因相关肽（CGRP），似乎也参与其中，并且可能与组胺或缓激肽相互作用。最近的研究表明，含有神经肽的牙髓内神经可能在牙髓的炎症和防御反应中发挥重要作用。
