Feldmann B, Färber D, Pontz B F
Kinderklinik der Technischen Universität München.
Radiologe. 1992 Jul;32(7):327-32.
In patients with chronic renal failure, aluminium, which is included in the dialysate or released from phosphate binders, cannot be eliminated adequately. It forms a deposit in the tissues and leads to intoxication. After a 6-month therapy with aluminium-containing phosphate binders in a non-dialysed baby with chronic renal insufficiency, an osteomalacia arose with distinct subepiphyseal and metaphyseal changes attributable to disorders of mineralization. The consequence of this was a "bone-within-bone" appearance and pathological fractures. After a change of therapy, the bone alterations receded within a few months. Simultaneously, the distinctly elevated serum level of aluminium fell. Therefore, aluminium should be avoided in non-dialysed children with chronic renal insufficiency.
在慢性肾衰竭患者中，透析液中所含的或从磷结合剂中释放出的铝无法被充分清除。它会在组织中形成沉积物并导致中毒。在一名患有慢性肾功能不全的未透析婴儿中，使用含铝磷结合剂进行6个月的治疗后，出现了骨软化症，伴有明显的骨骺下和干骺端改变，这归因于矿化障碍。其结果是出现“骨中骨”外观和病理性骨折。改变治疗方法后，骨骼改变在几个月内消退。同时，明显升高的血清铝水平也下降了。因此，对于患有慢性肾功能不全的未透析儿童应避免使用铝。
