Marsden S N, Parkinson I S, Ward M K, Ellis H A, Kerr D N
Proc Eur Dial Transplant Assoc. 1979;16:588-96.
There is increasing evidence that aluminium accumulation in patients with impaired renal function has pathological consequences. The serum aluminium content of 45 patients with chronic renal failure was found to be significantly elevated when compared with normal subjects. A further rise in serum aluminium concentration was seen in patients with chronic renal failure when they were taking aluminium-containing phosphate binding agents. Patients with stable but moderately impaired renal function who are taking aluminium-containing phosphate binders for several years may be at risk from aluminium accumulation and the development of osteomalacia and encephalopathy as seen in patients on intermittent haemodialysis.
越来越多的证据表明，肾功能受损患者体内铝的蓄积具有病理后果。与正常受试者相比，45例慢性肾衰竭患者的血清铝含量显著升高。慢性肾衰竭患者服用含铝的磷酸盐结合剂时，血清铝浓度会进一步升高。肾功能稳定但中度受损且服用含铝磷酸盐结合剂数年的患者，可能存在铝蓄积以及出现骨软化症和脑病的风险，就像接受间歇性血液透析的患者那样。
