Pneumothorax after lung biopsy: prevention with transpleural placement of compressed collagen foam plugs.

The effectiveness of pleural sealing with a compressed collagen foam plug in preventing the development of pneumothorax was evaluated in a prospective, comparative study of 50 patients undergoing transthoracic needle biopsies. The 4-cm-long plug was deposited through the thin-walled guidance needle at the end of the procedure in a position where it would cross both the visceral and the parietal pleura. The prevalence of postbiopsy pneumothorax was 28% (seven of 25 patients) in the control group and 8% (two of 25 patients) in the plug group. In each study group, two patients with pneumothoraces required chest tubes. Although further experience is necessary, the authors conclude that transpleural collagen foam plug placement may be an effective supplement for transthoracic needle biopsies.