Savera Adnan T, Zarbo Richard J
Department of Pathology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Adv Anat Pathol. 2004 Mar;11(2):69-85. doi: 10.1097/00125480-200403000-00001.
Neoplastic myoepithelium is considered to be the key cellular participant in morphogenetic processes responsible for the variable histologic appearances of many salivary gland tumors. Nevertheless, controversy still exists concerning its participation in some types of salivary gland neoplasms. This has been largely due to the difficulty in fully characterizing the wide spectrum of morphologic and immunophenotypic expressions of neoplastic myoepithelium compared with the normal counterpart. However, in recent years, our understanding regarding the phenotypic, immunophenotypic, ultrastructural, and biochemical properties of myoepithelium has advanced. Here we discuss the role of neoplastic myoepithelium in the scope of salivary gland neoplasia and present this information from a practical diagnostic standpoint.
肿瘤性肌上皮细胞被认为是许多涎腺肿瘤形态发生过程中的关键细胞参与者，这些过程导致了多种组织学表现。然而，关于其在某些类型涎腺肿瘤中的参与情况仍存在争议。这主要是因为与正常对应物相比，难以全面描述肿瘤性肌上皮细胞广泛的形态学和免疫表型表达谱。然而，近年来，我们对肌上皮细胞的表型、免疫表型、超微结构和生化特性的认识有所进展。在此，我们从实际诊断的角度讨论肿瘤性肌上皮细胞在涎腺肿瘤形成过程中的作用，并呈现相关信息。
