[δNp63在涎腺肿瘤中的表达]
[Expression of deltaNp63 in salivary gland tumours].
作者信息
He Zhi-xiu, Li Yi-ning, Liu Lai-kui, He Hua-wei, Wang Dan
机构信息
Department of Pathology, West China Stomatological Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):126-8.
OBJECTIVE
To detect the expression of deltaNp63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors.
METHODS
Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain.
RESULTS
It was found that the expression of deltaNp63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of deltaNp63 is correlated directly with benign and malignant tumor.
CONCLUSION
deltaNp63 plays an important role in salivary gland tumours. deltaNp63 possesses some special activity that is characteristic of oncogene. p63 is a sensitive and highly specific marker of myoepithelial cells in salivary gland tumours and an additional marker for defining myoepithelial histogenesis. p63 is of definite clinical value in falicitating diagnosis and differential diagnosis.
目的
检测δNp63在涎腺肿瘤中的表达情况，并分析其在涎腺恶性肿瘤中的作用。
方法
收集68例经病理证实的涎腺肿瘤标本，对其进行HE染色和免疫组织化学SP法染色切片观察。
结果
发现δNp63在恶性肿瘤中表达逐渐增高，涎腺肿瘤的肌上皮细胞及基底细胞呈阳性，且δNp63的表达与肿瘤的良恶性直接相关。
结论
δNp63在涎腺肿瘤中起重要作用。δNp63具有某些癌基因的特殊活性。p63是涎腺肿瘤中肌上皮细胞敏感且高度特异的标志物，也是确定肌上皮组织发生的附加标志物。p63在协助诊断及鉴别诊断方面具有一定临床价值。
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