Kamata K, Sakamoto A, Kasuya Y
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Res Commun Chem Pathol Pharmacol. 1992 Mar;75(3):361-4.
The changes in sensitivity of the rat duodenum to ATP were examined in preparations from control rats and from rats with streptozotocin (STZ)-induced diabetes. ATP was able to relax the duodenum of control animals in a concentration-dependent manner and this relaxation was significantly increased in STZ-diabetic rats. In preparations from diabetic rats, relaxation responses to ATP were greater than those of age-matched control groups. These results suggest that functional changes or degeneration of non-adrenergic, non-cholinergic nerves in the myenteric plexus may occur in STZ-diabetic rats, and that these alterations may result in the increased sensitivity of the relaxation of the duodenum to ATP.
在对照大鼠和链脲佐菌素（STZ）诱导的糖尿病大鼠的十二指肠标本中，研究了大鼠十二指肠对ATP敏感性的变化。ATP能够以浓度依赖性方式松弛对照动物的十二指肠，并且在STZ糖尿病大鼠中这种松弛作用显著增强。在糖尿病大鼠的标本中，对ATP的松弛反应大于年龄匹配的对照组。这些结果表明，STZ糖尿病大鼠的肌间神经丛中可能发生了非肾上腺素能、非胆碱能神经的功能变化或退化，并且这些改变可能导致十二指肠对ATP松弛的敏感性增加。
