Domingo J L, Sanchez D J, Gomez M, Llobet J M, Corbella J
Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.
Res Commun Chem Pathol Pharmacol. 1992 Mar;75(3):369-72.
Vanadyl sulfate trihydrate was given by gavage to streptozotocin-induced diabetic rats for 21 days at doses of 0, 25, 50, or 75 mg/kg/day. In marked contrast to the reduction in plasma glucose observed in diabetic animals given vanadyl sulfate via drinking water, diabetic rats given vanadyl by gavage were not characterized by normoglycemia. Similarly, in contrast to the normalizing effect of vanadyl in drinking water, vanadyl by gavage had only a minimal influence on diabetes associated hyperphagia and polydipsia. Despite the lack of marked effect of vanadyl by gavage on the above parameters, tissue vanadium accumulation in the gavaged rats was similar to that reported for rats given vanadium by drinking water. The present results (taken together with previous data) show that the administration of vanadium by gavage is not a viable alternative to the use of insulin in diabetes treatment.
将硫酸氧钒三水合物以0、25、50或75毫克/千克/天的剂量通过灌胃给予链脲佐菌素诱导的糖尿病大鼠，持续21天。与通过饮用水给予硫酸氧钒的糖尿病动物中观察到的血糖降低形成显著对比的是，通过灌胃给予硫酸氧钒的糖尿病大鼠并未表现出血糖正常。同样，与饮用水中钒的正常化作用相反，灌胃给予的钒对糖尿病相关的多食和多饮仅有极小的影响。尽管灌胃给予的钒对上述参数缺乏显著作用，但灌胃大鼠的组织钒积累与通过饮用水给予钒的大鼠所报道的情况相似。目前的结果（与先前的数据一起）表明，在糖尿病治疗中，通过灌胃给予钒并非使用胰岛素的可行替代方法。
