Koyuturk Meral, Tunali Sevim, Bolkent Sehnaz, Yanardag Refiye
Department of Histology and Embryology, Faculty of Medicine, Kadir Has University, 80810-Gayrettepe, Turkey.
Biol Trace Elem Res. 2005 Jun;104(3):233-47. doi: 10.1385/BTER:104:3:233.
The aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given, some reduction of degenerative changes were detected. After 60 d of treatment, serum aspartate and alanine transaminase, alkaline phosphatase, blood glucose levels, liver lipid peroxidation, and nonenzymatic glycosylation significantly increased, but liver glutathione levels significantly decreased in the diabetic group. On the other hand, treatment with vanadyl sulfate reversed these effects. As a result, it might be concluded that vanadyl sulfate has a protective effect on damage of liver of streptozotocin-induced diabetic rats.
本研究的目的是探讨硫酸氧钒对正常大鼠和链脲佐菌素（65毫克/千克）诱导的糖尿病大鼠肝脏组织的微观和生化影响。以100毫克/千克的剂量通过灌胃给予硫酸氧钒。通过光学显微镜和透射电子显微镜观察糖尿病动物的退行性变化。虽然给予钒的糖尿病动物存在个体差异，但仍检测到退行性变化有所减轻。治疗60天后，糖尿病组血清天冬氨酸和丙氨酸转氨酶、碱性磷酸酶、血糖水平、肝脏脂质过氧化和非酶糖基化显著升高，但肝脏谷胱甘肽水平显著降低。另一方面，硫酸氧钒治疗可逆转这些效应。因此，可以得出结论，硫酸氧钒对链脲佐菌素诱导的糖尿病大鼠肝脏损伤具有保护作用。
