Manabe S, Izumikawa S, Asakuno K, Wada O, Kanai Y
Department of Hygiene & Preventive Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.
Environ Pollut. 1991;70(3):255-65. doi: 10.1016/0269-7491(91)90013-m.
Diesel-exhaust particles are known to contain mutagenic and carcinogenic chemicals. The aim of this study was to determine whether carcinogenic amino-alpha-carbolines and amino-gamma-carbolines are present in diesel-exhaust particles. These carcinogens which were originally isolated from pyrolysates of proteins and amino acids have been detected in diesel-exhaust particles obtained from two test vehicles as well as in standard materials of automobile-exhaust particles obtained from National Institute for Environmental studies. The levels of these carcinogens were far less than those of polycyclic aromatic hydrocarbons such as benzo[a]pyrene. However, the presence of these amino-alpha-carbolines and amino-gamma-carbolines in diesel-exhaust particles suggests that these compounds are environmental pollutants and also that diesel-exhaust is one of the sources of these carcinogens in the outdoor environment.
众所周知，柴油废气颗粒含有致突变和致癌化学物质。本研究的目的是确定柴油废气颗粒中是否存在致癌的氨基-α-咔啉和氨基-γ-咔啉。这些最初从蛋白质和氨基酸的热解产物中分离出来的致癌物，已在两辆测试车辆的柴油废气颗粒以及从国立环境研究所获得的汽车尾气颗粒标准物质中检测到。这些致癌物的含量远低于多环芳烃如苯并[a]芘的含量。然而，柴油废气颗粒中存在这些氨基-α-咔啉和氨基-γ-咔啉表明，这些化合物是环境污染物，并且柴油废气是室外环境中这些致癌物的来源之一。
