Randriamampita C, Trautmann A
Dépt de Biologie Cellulaire, Institut Cochin, INSERM U567, CNRS UMR 8104, 22, rue Méchain 75014 Paris, France.
Biol Cell. 2004 Feb;96(1):69-78. doi: 10.1016/j.biolcel.2003.10.008.
Interaction between a T cell and an antigen-presenting cell leads to the rapid formation of an immunological synapse allowing antigen detection by the T cell and the development of an immune response. Antigen detection triggers various cellular responses including a modest but sustained T cell Ca2+ increase. In this review are discussed a series of related questions. What are the various molecular events by which a T cell Ca2+ response can be triggered in the immunological synapse by a very small amount of antigen? How is Ca2+ released from intracellular stores and how can these stores remain empty for hours? Through which channels does Ca2+ influx takes place, and how is Ca2+ influx coupled to Ca2+ release from intracellular stores? What are the main immediate and indirect cellular targets of the Ca2+ increase?
T细胞与抗原呈递细胞之间的相互作用会迅速形成免疫突触，使T细胞能够检测抗原并引发免疫反应。抗原检测会触发各种细胞反应，包括T细胞内钙离子适度但持续的增加。本综述讨论了一系列相关问题。在免疫突触中，极少量抗原通过哪些不同的分子事件触发T细胞的钙离子反应？钙离子如何从细胞内储存库释放，以及这些储存库如何能在数小时内保持排空状态？钙离子通过哪些通道流入，以及钙离子流入如何与细胞内储存库释放钙离子相偶联？钙离子增加的主要直接和间接细胞靶点是什么？
