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[在人体盘尾丝虫病中,乙胺嗪作用下皮肤内旋盘尾丝虫微丝蚴变性的超微结构特征]

[Ultrastructural aspects of the degeneration of the dermal microfilaria O. volvulus under the effect of diethylcarbamazine in human onchocerciasis].

作者信息

Rougemont A, Mattei X, Discamps C, Loreal E, Zander N, Mazelet J R

出版信息

C R Seances Soc Biol Fil. 1978;172(2):397-402.

PMID:150934
Abstract

Early modifications observed by previous authors are confirmed. More over, some later modifications are described where microfilariae are completely destroyed and removed by phagocytic cells. The theory concerning the mode of action of DEC on microfilariae in vivo is not confirmed (absence of extracellular "coarse particulate material", which is actually the unique morphological finding which leads the previous authors to assess the presence of immune complexes at the surface of microfilariae).

摘要

先前作者观察到的早期变化得到了证实。此外,还描述了一些后期变化,其中微丝蚴被吞噬细胞完全破坏并清除。关于乙胺嗪在体内对微丝蚴作用方式的理论未得到证实(不存在细胞外“粗颗粒物质”,而这实际上是先前作者评估微丝蚴表面存在免疫复合物的唯一形态学发现)。

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