Koot R W, de Heer K, Oort F J, Hulshof M C C M, Bosch D A, de Haes J C J M
Department of Neurosurgery, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Eur J Cancer. 2004 May;40(7):1013-20. doi: 10.1016/j.ejca.2004.01.018.
As quality of life (QoL) is perhaps the most important outcome for patients treated for glioblastoma multiforme (GBM), we measured QoL in GBM patients after brachytherapy. QoL was assessed by questionnaires for both patients and partners before brachytherapy and at various times during follow-up in 21 GBM patients by an extension of the Rotterdam Symptom Checklist (e-RSCL), consisting of four subscales. The Karnofsky Performance Scale (KPS) was also measured. Analysis of variance was done to evaluate the direct effect of brachytherapy (visit 1-2, short-term) and during follow up (visit 1-4, longer-term). Significant short-term effects were found for two subscales of the e-RSCL. Longer-term effects were found for all four subscales and for the KPS. A high correlation between partner and patient's QoL assessment was found. QoL in GBM patients after brachytherapy can therefore be carefully monitored with a subjective instrument such as the e-RSCL. Patients and partners experience QoL equally.
由于生活质量（QoL）可能是多形性胶质母细胞瘤（GBM）患者治疗后最重要的结果，我们测量了GBM患者近距离放射治疗后的生活质量。通过扩展鹿特丹症状清单（e-RSCL）（由四个子量表组成），在21例GBM患者近距离放射治疗前以及随访期间的不同时间，使用问卷对患者及其伴侣的生活质量进行评估。同时也测量了卡诺夫斯基功能状态量表（KPS）。采用方差分析来评估近距离放射治疗的直接效果（第1-2次就诊，短期）以及随访期间（第1-4次就诊，长期）的效果。在e-RSCL的两个子量表中发现了显著的短期效果。在所有四个子量表以及KPS中发现了长期效果。发现伴侣和患者的生活质量评估之间存在高度相关性。因此，使用诸如e-RSCL这样的主观工具可以仔细监测GBM患者近距离放射治疗后的生活质量。患者和伴侣对生活质量的感受相同。
