Kim Soo Hyun, Oh Eui Geum, Lee Won Hee
Quality of Cancer Care Branch, Research Institute and Hospital, National Cancer Center, 809 Madu-Dong, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do, Korea.
Int J Nurs Stud. 2006 Nov;43(8):1047-56. doi: 10.1016/j.ijnurstu.2005.11.012. Epub 2006 Sep 6.
In patients with cirrhosis, quality of life (QOL) is seriously impaired and associated with particular symptoms such as fatigue, muscle cramps or pruritus. However, there is lack of evidence about the overall symptom experience in patients with cirrhosis, in addition, most studies on QOL have focused only on identifying the relationship between disease-related variables such as disease severity, etiology or serological markers and QOL.
This study aimed to describe symptom experience, psychological distress, and QOL in Korean patients with liver cirrhosis, and to identify the factors that predict their quality of life.
This study is a cross-sectional, descriptive design.
The participants were recruited over a 2-month period, September 27 to November 25, 2003 from the outpatient or inpatient departments of gastroenterology at two large university hospitals in Seoul, Korea.
There were 129 patients, mean age was 53.6 years, who met eligibility criteria and agreed to participate in the study.
Symptom experience was measured with a scale developed by the researchers through a literature review on liver cirrhosis. Psychological distress was measured with the anxiety/depression category from the modified Korean version of the profile of mood states (POMS) [Shin, 1996. A study on verification of the profile of mood states (POMS) for Korean elders. Journal of Korean Academic Nursing 26, 743-758], and QOL was measured with quality of life index (QLI) developed by Ferrans and Powers [1985, Quality of life index: development and psychometric properties. Advances in Nursing Science 8, 15-24. ].
The results indicated that (1) overall symptom experience score was relatively low, major symptoms needing a management were fatigue, ascites and/or edema, and muscle cramps; (2) the mean score of psychological distress revealed mild to moderate levels of anxiety and depression; (3) quality of life was found to be seriously impaired; (4) psychological distress, employment status, and symptom experience were significant predictors of QOL, and explained 29.8% of the total variance.
These results indicate that symptom management, which includes attention to associated psychological intervention, is imperative for improvement in the QOL in Korean patients with liver cirrhosis.
在肝硬化患者中，生活质量（QOL）严重受损，并与疲劳、肌肉痉挛或瘙痒等特定症状相关。然而，目前缺乏关于肝硬化患者整体症状体验的证据，此外，大多数关于生活质量的研究仅侧重于确定疾病严重程度、病因或血清学标志物等疾病相关变量与生活质量之间的关系。
本研究旨在描述韩国肝硬化患者的症状体验、心理困扰和生活质量，并确定预测其生活质量的因素。
本研究为横断面描述性设计。
2003年9月27日至11月25日的两个月期间，从韩国首尔两家大型大学医院的胃肠病科门诊或住院部招募参与者。
共有129名患者，平均年龄为53.6岁，符合入选标准并同意参与研究。
症状体验通过研究人员通过对肝硬化文献综述开发的量表进行测量。心理困扰用改良版韩国情绪状态量表（POMS）的焦虑/抑郁类别进行测量[Shin，1996。韩国老年人情绪状态量表（POMS）的验证研究。韩国学术护理杂志26，743 - 758]，生活质量用Ferrans和Powers开发的生活质量指数（QLI）进行测量[1985，生活质量指数：发展与心理测量特性。护理科学进展8，15 - 24]。
结果表明：（1）整体症状体验得分相对较低，需要管理的主要症状是疲劳、腹水和/或水肿以及肌肉痉挛；（2）心理困扰的平均得分显示焦虑和抑郁程度为轻度至中度；（3）发现生活质量严重受损；（4）心理困扰、就业状况和症状体验是生活质量的重要预测因素，解释了总方差的29.8%。
这些结果表明，包括关注相关心理干预的症状管理对于改善韩国肝硬化患者的生活质量至关重要。
