Giménez Mónica, Junqué Carme, Narberhaus Ana, Caldú Xavier, Segarra Dolors, Vendrell Pere, Bargalló Núria, Mercader Josep M
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
Neuroreport. 2004 Mar 22;15(4):703-7. doi: 10.1097/00001756-200403220-00026.
In addition to the study of pathological conditions, magnetic resonance spectroscopy can provide useful information about brain-behavior relationships in normal subjects. Recently, there have been reports of correlations between N-acetylaspartate (NAA) values and cognitive functions in normal adults. We tested the possible specific relationship between the NAA/choline (Cho) ratio in the medial temporal lobe and memory performance in normal adolescents. The medial temporal NAA/Cho ratio was unrelated to age, gender and general intelligence but presented a clear correlation with several memory measures. In the regression analysis two memory variables (RAVLT learning and a face-name recognition task) explained 55.6% of NAA/Cho variance. We conclude that NAA values in the medial temporal lobe are related to memory abilities but not to global intelligence in normal adolescent subjects.
除了对病理状况的研究外，磁共振波谱还可以提供有关正常受试者脑-行为关系的有用信息。最近，有报道称正常成年人的N-乙酰天门冬氨酸（NAA）值与认知功能之间存在相关性。我们测试了正常青少年内侧颞叶中NAA/胆碱（Cho）比值与记忆表现之间可能存在的特定关系。内侧颞叶的NAA/Cho比值与年龄、性别和一般智力无关，但与几种记忆测量方法呈现出明显的相关性。在回归分析中，两个记忆变量（雷伊听觉词语学习测验学习和面孔-名字识别任务）解释了NAA/Cho方差的55.6%。我们得出结论，在正常青少年受试者中，内侧颞叶的NAA值与记忆能力有关，而与整体智力无关。
