Ariza Mar, Junqué Carme, Mataró Maria, Poca Maria A, Bargalló Núria, Olondo Miren, Sahuquillo Joan
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain.
Arch Neurol. 2004 Apr;61(4):541-4. doi: 10.1001/archneur.61.4.541.
Proton magnetic resonance spectroscopy can assess neurochemical sequelae in traumatic brain injury. Metabolic abnormalities are present in the acute or subacute period in patients with traumatic brain injury and correlate with outcome on clinical scales.
To investigate the use of proton magnetic resonance spectroscopy in detecting possible gray subcortical neurochemical impairments and their relationship with neuropsychological performance.
Group comparisons and correlations of brain metabolites with clinical and neuropsychological variables.
Metabolite concentrations were acquired from voxels localized to the basal ganglia and medial temporal region in 20 patients with long-term moderate and severe traumatic brain injury and 20 matched control subjects. Both groups underwent neuropsychological assessment.
N-acetylaspartate-choline-containing compounds ratios were decreased in patients in the basal ganglia (t = -3.28, P =.002) and medial temporal region (t = -3.52, P =.001). The basal ganglia ratio correlated to measures of speed, motor scanning, and attention.
Patients with long-term TBI present a regional correlation pattern that may help identify the neurological basis of cognitive sequelae in traumatic brain injury.
质子磁共振波谱可评估创伤性脑损伤中的神经化学后遗症。创伤性脑损伤患者在急性期或亚急性期存在代谢异常，且与临床量表的预后相关。
探讨质子磁共振波谱在检测可能的皮质下灰质神经化学损伤及其与神经心理表现关系中的应用。
脑代谢物与临床及神经心理变量的组间比较和相关性分析。
从20例长期中重度创伤性脑损伤患者和20例匹配的对照受试者位于基底节和内侧颞叶区域的体素中获取代谢物浓度。两组均接受神经心理评估。
基底节区（t = -3.28，P = 0.002）和内侧颞叶区（t = -3.52，P = 0.001）患者的N-乙酰天门冬氨酸与含胆碱化合物的比率降低。基底节区比率与速度、运动扫描和注意力测量值相关。
长期创伤性脑损伤患者呈现出一种区域相关性模式，这可能有助于确定创伤性脑损伤认知后遗症的神经学基础。
