Kayalioglu Gulgun, Balkan Burcu
Department of Anatomy, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
Neuroreport. 2004 Mar 1;15(3):421-3. doi: 10.1097/00001756-200403010-00008.
The participation of pedunculopontine tegmental nucleus in descending pain control mechanisms has been proposed. The aim of this study was to investigate NADPH-d and c-Fos reactivity in the pedunculopontine tegmental nucleus following noxious peripheral stimulation. Formalin induced hind paw inflammation in the rat resulted in bilateral increase of Fos and NADPH-d expression in the pedunculopontine tegmental nucleus. Approximately 30% of labelled cells were double-labelled. Close proximity to NADPH-d labelled neuronal processes with Fos-labelled nuclei were observed. This anatomical relationship supports the hypothesis that pedunculopontine tegmental nucleus is involved in pain modulation and proposes a new explanation for the presence of nitric oxide in this nucleus.
有人提出脑桥被盖脚核参与下行性疼痛控制机制。本研究旨在探讨外周伤害性刺激后脑桥被盖脚核中还原型辅酶II黄递酶（NADPH-d）和c-Fos的反应性。福尔马林诱导大鼠后爪炎症，导致脑桥被盖脚核中Fos和NADPH-d表达双侧增加。约30%的标记细胞为双标细胞。观察到Fos标记的细胞核与NADPH-d标记的神经元突起紧密相邻。这种解剖学关系支持了脑桥被盖脚核参与疼痛调制的假说，并为该核中一氧化氮的存在提出了新的解释。
