蛇毒凝血酶样酶：从爬虫酶到现在
Snake venom thrombin-like enzymes: from reptilase to now.
作者信息
Castro H C, Zingali R B, Albuquerque M G, Pujol-Luz M, Rodrigues C R
机构信息
Departamento de Biologia Celular e Molecular, IB-CEG, Universidade Federal Fluminense, Niterói, 24001-970 Rio de Janeiro, Brazil.
出版信息
Cell Mol Life Sci. 2004 Apr;61(7-8):843-56. doi: 10.1007/s00018-003-3325-z.
Abstract
The snake venom thrombin-like enzymes (SVTLEs) comprise a number of serine proteases functionally and structurally related to thrombin. Until recently, only nine complete sequences of this subgroup of the serine protease family were known. Over the past 5 years, the primary structure of several SVTLEs has been characterized, and now this family includes several members. Of particular interest is their possible use in pathologies such as thrombosis. The aim of the present review is to summarize the state of the art concerning the evolutionary, structural and biological features of the SVTLEs.
摘要
蛇毒类凝血酶（SVTLEs）包含多种在功能和结构上与凝血酶相关的丝氨酸蛋白酶。直到最近，人们仅知晓该丝氨酸蛋白酶家族这一亚组的九个完整序列。在过去五年中，几种蛇毒类凝血酶的一级结构已得到表征，如今这个家族包含了多个成员。特别令人感兴趣的是它们在诸如血栓形成等病理学方面的潜在用途。本综述的目的是总结关于蛇毒类凝血酶的进化、结构和生物学特性的现有技术水平。
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