Stevens David A
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA.
Clin Infect Dis. 2004 Apr 15;38(8):1131-6. doi: 10.1086/382882. Epub 2004 Apr 5.
Invasive aspergillosis is a devastating and increasingly common disease, seen almost exclusively in immunosuppressed patients. Immunizing an immunocompromised host would seem to be a formidable task; however, virulence factors and immunogens of the pathogen have now been identified and could be targeted, mapping of the genome sequence of the pathogen will soon be completed, and the protective host immune responses and cytokine networking are better understood. These facts, together with recent advances in vaccine science, make consideration of such an approach now possible. Some populations that are at risk for aspergillosis might be likely candidates for receiving the first vaccinations against aspergillosis, or vaccination of a stem cell donor might be considered in some circumstances. Successful immunizations have been demonstrated in turkeys and mice.
侵袭性曲霉病是一种具有毁灭性且日益常见的疾病，几乎仅见于免疫抑制患者。对免疫功能低下的宿主进行免疫接种似乎是一项艰巨的任务；然而，目前已确定了病原体的毒力因子和免疫原并可将其作为靶点，病原体基因组序列的图谱绘制即将完成，并且对宿主的保护性免疫反应和细胞因子网络也有了更好的了解。这些事实，再加上疫苗科学的最新进展，使得现在考虑采用这种方法成为可能。一些有患曲霉病风险的人群可能是首批接种抗曲霉病疫苗的合适对象，或者在某些情况下可以考虑对干细胞供体进行接种。在火鸡和小鼠身上已证明免疫接种是成功的。
