Michels Karin B, Xue Fei, Brandt Lena, Ekbom Anders
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Int J Cancer. 2004 Jun 20;110(3):449-51. doi: 10.1002/ijc.20155.
Preliminary data are available on the coexistence of primary hyperparathyroidism and breast carcinoma. To further understand the association between hyperparathyroidism and breast cancer, we conducted a record-linkage study in Sweden using the Swedish Cancer Registry from 1958-1997. A total of 9,835 women who underwent surgery for primary parathyroid adenoma were followed to evaluate the hypothesis that a history of primary hyperparathyroidism increases the risk of subsequent breast cancer. During 99,929 person-years of follow-up, 331 cases of newly diagnosed breast cancer were reported. The number of expected breast cancers in this population was 260.0. This resulted in a standardized incidence ratio of 1.27 (95% confidence interval [CI] = 1.14-1.41). The relation persisted over time after the surgical removal of the parathyroid adenoma. Possible explanations for the observed association are a shared etiology including genetic and environmental factors such as early life radiation, and hypercalcemia after the overproduction of parathyroid hormone, which may increase breast cancer incidence.
目前已有关于原发性甲状旁腺功能亢进症与乳腺癌并存的初步数据。为了进一步了解甲状旁腺功能亢进症与乳腺癌之间的关联，我们在瑞典利用1958年至1997年的瑞典癌症登记处进行了一项记录链接研究。总共对9835名接受原发性甲状旁腺腺瘤手术的女性进行了随访，以评估原发性甲状旁腺功能亢进症病史会增加后续患乳腺癌风险这一假设。在99929人年的随访期间，报告了331例新诊断的乳腺癌病例。该人群中预期的乳腺癌病例数为260.0。这导致标准化发病率比为1.27（95%置信区间[CI]=1.14 - 1.41）。在手术切除甲状旁腺腺瘤后，这种关联随时间持续存在。对观察到的关联的可能解释包括共同的病因，如早期生活辐射等遗传和环境因素，以及甲状旁腺激素过度分泌后的高钙血症，这可能会增加乳腺癌的发病率。
