Bartosová L, Frydrych M, Mokrý P, Brunclík V, Bahníková M
Ustav humánní farmakologie a toxikologie Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno.
Ceska Slov Farm. 2004 Mar;53(2):80-4.
With the use of normotensive laboratory Wistar strain rats, changes in heart rate induced by three newly synthesized potential ultrashort beta-blockers were tested. The animals were administered the tested substances intravenously in general anesthesia. In all animals, heart rate was measured at predetermined time intervals. All obtained values were converted into the per cents of the heart rate deviation and the results were statistically processed. Using F-test, variability of dispersion was determined, and using Student t-test, statistical significance of the particular change was determined. In all three substances tested, a statistically demonstrable short-time bradycardiac effect was observed. The most marked decrease took place in the first minute after intravenous administration. Substance 44Bu induced the significantly deepest decrease in heart rate (by 13.00%), which lasted longest. No statistically significant difference was found between the actions of substances 42Bu and 43Bu. In all three substances tested, marked changes in the ECG record were observed immediately after intravenous administration. PQ and QT intervals and QRS complex were prolonged, and marked S wave, elevation of the T wave, and a decrease in R wave occurred. The changes were accompanied by a change in the electric cardiac axis.
使用血压正常的实验用Wistar品系大鼠，测试了三种新合成的潜在超短效β受体阻滞剂引起的心率变化。在全身麻醉下给动物静脉注射受试物质。在所有动物中，按预定时间间隔测量心率。所有获得的值都换算成心率偏差的百分比，并对结果进行统计学处理。使用F检验确定离散度的变异性，使用学生t检验确定特定变化的统计学显著性。在所测试的三种物质中，均观察到统计学上可证明的短时间心动过缓效应。最显著的心率下降发生在静脉注射后的第一分钟。物质44Bu引起的心率下降最为显著（下降了13.00%），且持续时间最长。在物质42Bu和43Bu的作用之间未发现统计学上的显著差异。在所测试的三种物质中，静脉注射后立即观察到心电图记录有明显变化。PQ和QT间期以及QRS波群延长，出现明显的S波、T波抬高和R波降低。这些变化伴随着心电轴的改变。
