[沃州唇-上颌-腭裂的流行病学]

[Epidemiology of lip-maxilla-palate clefts in the canton of Vaud].

作者信息

Addor Marie-Claude, Feldmeyer Laurence, Hohlfeld Judith, Schorderet Daniel F

机构信息

Service de Génétique Médicale, CHUV, Lausanne.

出版信息

Rev Med Suisse Romande. 2003 Aug;123(8):501-5.

PMID:15095647

Abstract

Epidemiological variables in oral clefts were examined in a cohort of patients with congenital malformations from the canton of Vaud in Switzerland during the years 1990-1999. Among 77'259 newborns or foetuses, 144 cases of oral clefts were identified in the Registre Vaudois des Anomalies Congénitales (RVAC), yielding a total prevalence of 18.6 per 10'000. These clefts consisted of 84 (58%) cases of cleft lip with or without cleft palate (CL/P) and 60 (42%) cases of cleft palate only (CP). Associated anomalies were found in 45% of cases. Our results are compared with previous reports in other parts of Europe.

摘要

1990年至1999年期间，对瑞士沃州一组先天性畸形患者的口腔裂隙的流行病学变量进行了研究。在77259名新生儿或胎儿中，在沃州先天性畸形登记处（RVAC）确定了144例口腔裂隙病例，总患病率为每10000人中有18.6例。这些裂隙包括84例（58%）唇裂伴或不伴腭裂（CL/P）和60例（42%）仅腭裂（CP）。45%的病例发现有相关异常。我们的结果与欧洲其他地区以前的报告进行了比较。