Johnson Candice Y, Honein Margaret A, Hobbs Charlotte A, Rasmussen Sonja A
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Prenat Diagn. 2009 Sep;29(9):833-9. doi: 10.1002/pd.2293.
The aims of this study were to determine how frequently orofacial clefts were diagnosed prenatally and to investigate factors associated with prenatal diagnosis.
We included 2298 mothers from the National Birth Defects Prevention Study, each of whom gave birth to a child with an orofacial cleft, and assessed associated factors using logistic regression.
The frequencies of prenatal diagnosis for cleft lip and palate, cleft lip only, and cleft palate only were 33.3%, 20.3%, and 0.3%, respectively. Among cases with cleft lip with or without cleft palate, cleft type, geographic location, maternal body mass index, household income, year of infant's birth, and presence of multiple birth defects were significantly associated with receiving a prenatal diagnosis.
In the majority of infants with orofacial clefts, a prenatal diagnosis was not made. Receiving a prenatal diagnosis was significantly associated with several infant and maternal characteristics.
本研究旨在确定产前诊断口面部裂隙的频率，并调查与产前诊断相关的因素。
我们纳入了国家出生缺陷预防研究中的2298名母亲，她们各自生育了一名患有口面部裂隙的儿童，并使用逻辑回归评估相关因素。
唇腭裂、单纯唇裂和单纯腭裂的产前诊断频率分别为33.3%、20.3%和0.3%。在有或没有腭裂的唇裂病例中，裂隙类型、地理位置、母亲体重指数、家庭收入、婴儿出生年份以及是否存在多种出生缺陷与接受产前诊断显著相关。
在大多数患有口面部裂隙的婴儿中，未进行产前诊断。接受产前诊断与一些婴儿和母亲的特征显著相关。
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