Ellis Terri N, Beaman Blaine L
Department of Medical Microbiology and Immunology, University of California School of Medicine, University of California, Davis, CA 95616, USA.
Immunology. 2004 May;112(1):2-12. doi: 10.1111/j.1365-2567.2004.01849.x.
As current research illuminates the dynamic interplay between the innate and acquired immune responses, the interaction and communication between these two arms has yet to be fully investigated. Polymorphonuclear neutrophils (PMNs) and interferon-gamma (IFN-gamma) are known critical components of innate and acquired immunity, respectively. However, recent studies have demonstrated that these two components are not entirely isolated. Treatment of PMNs with IFN-gamma elicits a variety of responses depending on stimuli and environmental conditions. These responses include increased oxidative burst, differential gene expression, and induction of antigen presentation. Many of these functions have been overlooked in PMNs, which have long been classified as terminal phagocytic cells incapable of protein synthesis. As this review reports, the old definition of the PMN is in need of an update, as these cells have demonstrated their ability to mediate the transition between the innate and acquired immune responses.
随着当前研究揭示了先天免疫反应和获得性免疫反应之间的动态相互作用，这两个分支之间的相互作用和交流尚未得到充分研究。多形核中性粒细胞（PMN）和干扰素-γ（IFN-γ）分别是已知的先天免疫和获得性免疫的关键组成部分。然而，最近的研究表明，这两个组成部分并非完全孤立。用IFN-γ处理PMN会根据刺激和环境条件引发多种反应。这些反应包括氧化爆发增加、基因表达差异以及抗原呈递的诱导。PMN中的许多这些功能一直被忽视，长期以来PMN被归类为无法进行蛋白质合成的终末吞噬细胞。正如本综述所报道的，PMN的旧定义需要更新，因为这些细胞已证明它们能够介导先天免疫反应和获得性免疫反应之间的转变。
