Arias-Mendoza Fernando, Brown Truman R
Hatch Center for MR Research, Department of Radiology, Columbia University, New York, NY 10032, USA.
Dis Markers. 2003;19(2-3):49-68. doi: 10.1155/2004/419095.
Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) has been utilized to study energy, carbohydrate, and phospholipid metabolism in vitro and in vivo in live tissues non-invasively. Despite its lack of sensitivity, its application has extended to in situ human tissues and organs since proper signal localization was devised. Follow-up of phosphocreatine in neuromuscular diseases and schizophrenia and follow-up of phospholipid-related molecules in tumors are described here to demonstrate the value of 31P-MRS as an imaging technique to determine in vivo markers of disease and in the diagnosis, prognosis, and follow-up of human diseases.
磷磁共振波谱（31P-MRS）已被用于在体外和体内对活组织中的能量、碳水化合物和磷脂代谢进行非侵入性研究。尽管其灵敏度欠佳，但自从设计出合适的信号定位方法后，其应用已扩展到原位人体组织和器官。本文描述了在神经肌肉疾病和精神分裂症中对磷酸肌酸的跟踪以及在肿瘤中对磷脂相关分子的跟踪，以证明31P-MRS作为一种成像技术在确定疾病体内标志物以及人类疾病的诊断、预后和跟踪方面的价值。
