Sedgh Gilda, Spiegelman Donna, Larsen Ulla, Msamanga Gernard, Fawzi Wafaie W
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
AIDS. 2004 Apr 30;18(7):1043-9. doi: 10.1097/00002030-200404300-00013.
To examine the association between breastfeeding and disease progression among HIV-infected women in Dar es Salaam, Tanzania.
Cohort study design with Cox proportional hazards models.
The relative risk of death comparing women who recently had been breastfeeding to those who were not breastfeeding was 0.47 (95% confidence interval, 0.18-1.20). Neither breastfeeding status nor the duration of exclusive or partial breastfeeding was associated with HIV-1 disease progression, represented by death or development of a low CD4 cell count, anemia or excessive weight loss, in multivariate analyses. These associations remained insignificant when women with relatively low and high CD4 cell counts were analyzed separately.
There is insufficient evidence to support the hypothesis that breastfeeding is detrimental to the health of HIV-infected women.
研究坦桑尼亚达累斯萨拉姆市感染艾滋病毒的女性中母乳喂养与疾病进展之间的关联。
采用Cox比例风险模型进行队列研究设计。
近期进行母乳喂养的女性与未进行母乳喂养的女性相比，死亡相对风险为0.47（95%置信区间，0.18 - 1.20）。在多变量分析中，母乳喂养状况以及纯母乳喂养或部分母乳喂养的持续时间均与以死亡或低CD4细胞计数、贫血或体重过度减轻为代表的HIV - 1疾病进展无关。当分别分析CD4细胞计数相对较低和较高的女性时，这些关联仍然不显著。
没有足够的证据支持母乳喂养对感染艾滋病毒的女性健康有害这一假设。
