Cardoso Ana R, Gonçalves Cristina, Pascoalinho Dulce, Gil Carla, Ferreira António F, Bártolo Inês, Taveira Nuno
Hospital Nossa Senhora da Graça, Tomar, Portugal.
AIDS. 2004 Apr 30;18(7):1071-4. doi: 10.1097/00002030-200404300-00018.
The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.
对真正血清学阴性的HIV-1感染的研究可能对HIV-1感染的诊断和预防具有重要意义。本文描述了一名艾滋病患者HIV血清学持续阴性的病例。基因和系统发育分析表明，她感染了由其血清学阳性且无症状的性伴侣传播的A2亚型HIV-1。临床和血清学结果不一致表明存在免疫缺陷，从而阻止了HIV-1特异性抗体的形成。
