Monti J M, Altier H, Ziman V
Eur J Pharmacol. 1978 Aug 1;50(3):183-6. doi: 10.1016/0014-2999(78)90349-7.
The actions of drugs interfering with central indolaminergic mechanisms were assessed on the Dopa-induced EEG synchronization in the rat. The increased slow wave activity observed during the first 30 min following Dopa (100 mg/kg) was significantly decreased by p-chlorophenylalanine (400 mg/kg), reserpine (4 and 8 mg/kg) and methysergide (16 mg/kg). Cyproheptadine was ineffective in this respect. Our findings lend support to the hypothesis that the initial synchronization after Dopa is related to the release of 5-hydroxytryptamine.
在大鼠中，评估了干扰中枢吲哚胺能机制的药物对多巴诱导的脑电图同步化的作用。给予多巴（100mg/kg）后最初30分钟内观察到的慢波活动增加，被对氯苯丙氨酸（400mg/kg）、利血平（4mg/kg和8mg/kg）以及麦角新碱（16mg/kg）显著降低。在这方面，赛庚啶无效。我们的研究结果支持了这样一种假说，即多巴后的初始同步化与5-羟色胺的释放有关。
