Mogilnicka E, Scheel-Krüger J, Klimek V, Golembiowska-Nikitin K
Pol J Pharmacol Pharm. 1977 Jan-Feb;29(1):31-8.
The effect of drugs blocking serotonin receptors: cyproheptadine, methysergide, and methergoline, and of serotonin synthesis inhibitor, p-chlorophenylalanine on the stereotyped behavior and number of rearings of the rats receiving apomorphine, amphetamine, nomifensine and 1,3-dimethyl-5-aminoadamantane was investigated. The blockade of serotonin receptors potentiates behavioral effects of dopamine agonists. It is concluded that central serotonin may play an inhibitory role, antagonistic to that of catecholamines.
研究了阻断5-羟色胺受体的药物（赛庚啶、甲基麦角新碱和麦角乙脲）以及5-羟色胺合成抑制剂对氯苯丙氨酸对接受阿扑吗啡、苯丙胺、诺米芬辛和1,3-二甲基-5-氨基金刚烷的大鼠刻板行为和竖毛次数的影响。5-羟色胺受体的阻断增强了多巴胺激动剂的行为效应。得出的结论是，中枢5-羟色胺可能起抑制作用，与儿茶酚胺的作用相反。
