Paton C M, Nagelkirk P R, Coughlin A M, Cooper J A, Davis G A, Hassouna H, Pivarnik J M, Womack C J
Human Energy Research Laboratory, Department of Kinesiology, Michigan State University, East Lansing, MI 48824, USA.
Eur J Appl Physiol. 2004 Jul;92(3):328-33. doi: 10.1007/s00421-004-1098-1. Epub 2004 Apr 20.
The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake (VO2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen (vWf:Ag), tissue plasminogen activator (tPA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using repeated measures analysis of variance. No significant differences were found between VO2max tests for treadmill time, VO2max, respiratory exchange ratio, maximal heart rate, or maximal blood lactate concentration. vWf:Ag was significantly elevated (P <0.05)following PC [198.4 (18.3)% normal] versus AC [174.5 (15.6)% normal] and remained elevated 1-h post-exercise [179.4 (16.4)% normal for PC vs 158.6 (13.8)% normal for AC]. There were no differences between tests for tPA or PAI-1 activity, although tPA antigen was significantly elevated following PC versus AC (P <0.05). Following the cool-down, hematocrit was higher (P <0.05) for the PC test [48.90 (0.36)] compared with AC [47.43 (0.51)]. An AC reduces post-exercise vWf:Ag and tPA antigen without affecting tPA or PAI-1 activity.
本研究的目的是确定运动后主动放松对血管性血友病因子和纤维蛋白溶解的影响。10名受试者进行了两次最大摄氧量（VO2max）测试，随后进行10分钟的被动（PC）或主动（AC）放松。在运动前、运动后、PC/AC后以及运动后1小时采集血样，分析血管性血友病因子抗原（vWf:Ag）、组织纤溶酶原激活物（tPA）抗原和活性以及纤溶酶原激活物抑制剂-1（PAI-1）活性。使用重复测量方差分析对数据进行分析。在跑步机运动时间、VO2max、呼吸交换率、最大心率或最大血乳酸浓度的VO2max测试之间未发现显著差异。与AC组[174.5（15.6）%正常]相比，PC组[198.4（18.3）%正常]后vWf:Ag显著升高（P<0.05），且在运动后1小时仍保持升高[PC组为179.4（16.4）%正常，AC组为158.6（13.8）%正常]。tPA或PAI-1活性测试之间没有差异，尽管PC组后tPA抗原显著高于AC组（P<0.05）。放松后，PC测试的血细胞比容[48.90（0.36）]高于AC组[47.43（0.51）]（P<0.05）。主动放松可降低运动后vWf:Ag和tPA抗原，而不影响tPA或PAI-1活性。
