Iarmolinskiĭ D G, Kartel N A, Ermak G, Demidchik Iu E, Figge J
Tsitol Genet. 2004 Jan-Feb;38(1):9-14.
The "rare" alleles of HRas1 gene minisatellite are well-known factor of predisposition to many kinds of cancer. We have studied HRas1 minisatellite frequencies among patients with papillary thyroid cancer which is related to consequences of Chernobyl accident. The HRas1 minisatellite was analysed in 32 patients who suffered from papillary carcinoma and underwent operation in 1996-2001 and in 75 Belorussian residents. Of 64 HRas1 alleles revealed in patients 14 were defined as "rare" (21.9%); in the control group we have detected 17 "rare" alleles (11.3%) of the examined 150 alleles. The higher frequency of "rare" HRas1 minisatellite alleles in patient group was statistically significant (p < 0.01). We can suppose that the "rare" alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident.
HRas1基因微卫星的“稀有”等位基因是多种癌症易感性的一个众所周知的因素。我们研究了与切尔诺贝利事故后果相关的甲状腺乳头状癌患者中HRas1微卫星的频率。对1996年至2001年期间患有乳头状癌并接受手术的32名患者以及75名白俄罗斯居民的HRas1微卫星进行了分析。在患者中检测到的64个HRas1等位基因中，有14个被定义为“稀有”（21.9%）；在对照组中，在检测的150个等位基因中我们检测到了17个“稀有”等位基因（11.3%）。患者组中“稀有”HRas1微卫星等位基因的较高频率具有统计学意义（p < 0.01）。我们可以推测，HRas1微卫星的“稀有”等位基因与切尔诺贝利事故后儿童和青少年甲状腺乳头状癌形成风险的增加有关。
