Dósa Edit, Szabó Attila, Entz László, Selmeci László, Walentin Szilvia, Kleiber Mónika, Rugonfalvi Kiss Szabolcs, Hosszúfalusi Nóra, Füst György, Prohászka Zoltán
Semmelweis Egyetem, Altalános Orvostudományi Kar, Er- és Szívsebészeti Klinika, Budapest.
Orv Hetil. 2004 Mar 14;145(11):567-72.
C-reactive protein (CRP) is a well-known acute phase protein. The concentration of CRP in serum is increased in response to inflammatory stimuli. Increased levels serve to identify organic disease, to monitor disease activity and to assist differential diagnosis.
The aim of the authors' cross-sectional study was to determine CRP distribution of the healthy Hungarian population.
207 (79 male, 128 female; mean age: 4 +/- 68 years) healthy blood donors were enrolled for the study. The following parameters were registered: sex, age, body mass index, smoking habits, diabetes mellitus and blood pressure. Serum samples were assayed for total serum cholesterol, triglyceride, erythrocyte sedimentation rate, hemoglobin and for white blood cell count. CRP was measured by ultrasensitive, particle enhanced immunoturbidimetric assay.
CRP levels were less than 5 mg/L in 81% of the blood donors. Mean level of CRP in the study population was 3.57 mg/L (SD +/- 5.33); the distribution was comparable to the data of already published studies. Comparing laboratory parameters and the risk status stratified according to CRP levels (less or more than 5 mg/L) significant differences were found in BMI (p = 0.0015), in total serum cholesterol (p = 0.0136), in triglyceride (p < 0.0001), in erythrocyte sedimentation rate (p < 0.0001), in white blood cell (p = 0.0007) and granulocyte count (p = 0.0014). Significant correlation was found between age and the concentration CRP (r = 0.22; p = 0.0011).
The CRP measurement by ultrasensitive method is suitable for cardiovascular risk estimation in apparently healthy men and women. Risk prediction adapted for the Hungarian situation may be stimulated by these data.
C反应蛋白（CRP）是一种众所周知的急性期蛋白。血清中CRP的浓度会因炎症刺激而升高。其水平升高有助于识别器质性疾病、监测疾病活动并辅助鉴别诊断。
作者进行这项横断面研究的目的是确定匈牙利健康人群的CRP分布情况。
207名（79名男性，128名女性；平均年龄：4±68岁）健康献血者参与了该研究。记录了以下参数：性别、年龄、体重指数、吸烟习惯、糖尿病和血压。对血清样本进行了总血清胆固醇、甘油三酯、红细胞沉降率、血红蛋白和白细胞计数的检测。CRP采用超敏、颗粒增强免疫比浊法进行测定。
81%的献血者CRP水平低于5mg/L。研究人群中CRP的平均水平为3.57mg/L（标准差±5.33）；该分布与已发表研究的数据相当。比较实验室参数和根据CRP水平（低于或高于5mg/L）分层的风险状态，发现体重指数（p = 0.0015）、总血清胆固醇（p = 0.0136）、甘油三酯（p < 0.0001）、红细胞沉降率（p < 0.0001）、白细胞（p = 0.0007）和粒细胞计数（p = 0.0014）存在显著差异。年龄与CRP浓度之间存在显著相关性（r = 0.22；p = 0.0011）。
采用超敏方法测定CRP适用于对看似健康的男性和女性进行心血管风险评估。这些数据可能会推动针对匈牙利情况的风险预测。
