青蛙骨骼肌在舒张和收缩状态下基于肌球蛋白的子午线X射线反射的建模分析。
Modeling analysis of myosin-based meridional X-ray reflections from frog skeletal muscles in relaxed and contracting states.
作者信息
Oshima Kanji, Takezawa Yasunori, Sugimoto Yasunobu, Kiyotoshi Maya, Wakabayashi Katsuzo
机构信息
Division of Biophysical Engineering, School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.
出版信息
Adv Exp Med Biol. 2003;538:243-9. doi: 10.1007/978-1-4419-9029-7_23.
Analysis of the myosin-based meridional intensity data in the X-ray diffraction patterns of live frog skeletal muscles was performed to propose a more precise model for a myosin crown periodicity and an axial disposition of two-headed crossbridges along the thick filament in a sarcomere. Modeling studies revealed that the thick filament has a mixed structure of two different periodicities of the myosin crossbridge crown arrangement and that the crown periodicity and the axial disposition of crossbridges are altered when muscle goes from the relaxed state to the contracting state. Factors that primarily affect the meridional intensities were examined.
对活蛙骨骼肌X射线衍射图谱中基于肌球蛋白的子午线强度数据进行了分析，以提出一个更精确的肌球蛋白冠周期性模型，以及双头横桥在肌节中沿粗肌丝的轴向排列模型。建模研究表明，粗肌丝具有肌球蛋白横桥冠排列的两种不同周期性的混合结构，并且当肌肉从松弛状态转变为收缩状态时，冠的周期性和横桥的轴向排列会发生改变。研究了主要影响子午线强度的因素。
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