Yiou René, Zini Laurent, Lecoeur Constant, Biserte Jacques, Abbou Claude, Atala Antony, Chopin Dominique
Service d'Urologie, Centre de Recherches Chirurgicales, CHU Henri Mondor, Créteil, France.
Prog Urol. 2004 Feb;14(1):93-9.
This article reviews cell therapy for muscle diseases and describes the development of a treatment for urethral sphincter insufficiency by muscle precursor cell (MPC) autograft. These studies were conducted in several successive steps, comprising: 1) comparative study of the cellular mechanisms of regeneration of skeletal striated muscle and urethral striated sphincter and development of a method of extraction of MPC; 2) creation of an animal model of sphincter injury reproducing chronic denervation lesions and fibrosis responsible for sphincter insufficiency in human; 3) study of the biology of intrasphincteric transplantation of MPC extracted from peripheral muscle, taking into account the interactions between these cells and the peripheral nervous system.
本文综述了用于肌肉疾病的细胞疗法，并描述了通过肌肉前体细胞（MPC）自体移植治疗尿道括约肌功能不全的进展。这些研究分几个连续步骤进行，包括：1）骨骼肌和尿道横纹括约肌再生细胞机制的比较研究以及MPC提取方法的开发；2）建立模拟人类因慢性去神经损伤和纤维化导致括约肌功能不全的括约肌损伤动物模型；3）研究从外周肌肉提取的MPC括约肌内移植的生物学特性，同时考虑这些细胞与外周神经系统之间的相互作用。
