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中枢和周围神经损伤后硬脂酰辅酶A去饱和酶-1的调节

Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions.

作者信息

Breuer Sebastian, Pech Katrin, Buss Armin, Spitzer Christoph, Ozols Juris, Hol Elly M, Heussen Nicole, Noth Johannes, Schwaiger Franz-Werner, Schmitt Andreas B

机构信息

Department of Neurology, University Medical School, Pauwelsstr 30, D-52074 Aachen, Germany.

出版信息

BMC Neurosci. 2004 Apr 20;5:15. doi: 10.1186/1471-2202-5-15.

DOI:10.1186/1471-2202-5-15
PMID:15099403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411035/
Abstract

BACKGROUND

Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.

RESULTS

In situ hybridization and immunohistochemistry demonstrated a strong up-regulation of SCD at mRNA and protein level in regenerating neurons of the rat facial nucleus whereas non-regenerating Clarke's and Red nucleus neurons did not show an induction of this gene.

CONCLUSION

This differential expression points to a functionally significant role for the SCD-1 in the process of regeneration.

摘要

背景

成熟轴突的中断会在神经元细胞体中激活一系列事件，这会导致从周围神经系统的功能再生到中枢神经系统中任何显著再生失败的各种结果。在轴突切断后的分子程序中似乎起重要作用的一个因素是硬脂酰辅酶A去饱和酶-1（SCD-1）。这种酶是将硬脂酸转化为油酸所必需的。除了其在膜合成中的作用外，油酸还可以作为一种神经营养因子，通过激活蛋白激酶C参与信号转导途径。

结果

原位杂交和免疫组织化学表明，大鼠面神经核再生神经元中SCD在mRNA和蛋白质水平上有强烈的上调，而未再生的克拉克核和红核神经元未显示该基因的诱导。

结论

这种差异表达表明SCD-1在再生过程中具有功能上的重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/d5f665491a50/1471-2202-5-15-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/7d6de92d1368/1471-2202-5-15-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/43da032d76f1/1471-2202-5-15-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/17aa95eabdef/1471-2202-5-15-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/6805a78dcb06/1471-2202-5-15-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/d5f665491a50/1471-2202-5-15-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/7d6de92d1368/1471-2202-5-15-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/43da032d76f1/1471-2202-5-15-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/17aa95eabdef/1471-2202-5-15-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/6805a78dcb06/1471-2202-5-15-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08af/411035/d5f665491a50/1471-2202-5-15-5.jpg

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