[两种膜式血浆分离器治疗慢性重型乙型肝炎患者的疗效]

[The efficacy of two type of membrane plasma separator on the treatment of patients with chronic severe hepatitis B].

作者信息

Zhang Da-zhi, Zhao You-rong, Zhang Quan-hai, Wang Zhi-yi, Qin Bo, He Hua, Zhou Zhi, Guo Shu-hua

机构信息

The Institute for Viral Hepatitis, Chongqing Medical University, Chongqing 400010, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2004 Apr;12(4):208-9.

PMID:15099467

Abstract

OBJECTIVE

In order to compare the efficacy of two kinds of membrane plasma separator on the treatment of patients with severe hepatitis B.

METHODS

63 cases suffering from chronic severe hepatitis B were divided into two groups, 25 cases were treated with plasma exchange using Evacure-4A membrane plasma separator (A group) or 38 cases were using PS-06 membrane plasma separator (B group). Both of them also were treated with similar basic medical treatment. The level of serum total bilirubin, non-conjugated bilirubin, prothrombin time and albumin were tested at baseline and the end of the treatment with PE.

RESULTS

Evacure-4A and PS-06 membrane plasma separators can effientively remove bilirubin, the levels of serum total bilirubin, non-conjugated bilirubin of all patients were significantly decreased after treated with PE. In A group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (464.2+/-193.8)micromol/L to (279.4+/-158.7)micromol/L, (293.5+/-129.1)micromol/L to (175.5+/-106.7)micromol/L (t=5.45, 10.36, P<0.01) respectively. In B group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (493.2+/-126.9)micromol/L to (299.7+/-96.5)micromol/L, (300.2+/-74.3)micromol/L to (171.5+/-53.1)micromol/L (t=5.17, 12.04, P<0.01) respectively. The level of serum albumin increased after treated with PE in A and B groups, to contrast with PS-06, the increasing percentage of albumin was higher when the patients were treated with PE using Evacure-4A membrane plasma separator [(8.3+/-0.7) % vs. (3.4+/-9.3) %, t = 2.76, P<0.01].

CONCLUSION

Evacure-4A membrane plasma separator may be better than PS-06 membrane plasma separator on the treatment of patients with chronic severe hepatitis B.

摘要

目的

比较两种膜式血浆分离器治疗重型乙型肝炎患者的疗效。

方法

将63例慢性重型乙型肝炎患者分为两组，25例采用Evacure - 4A膜式血浆分离器进行血浆置换治疗（A组），38例采用PS - 06膜式血浆分离器进行血浆置换治疗（B组）。两组均给予相似的基础内科治疗。在血浆置换治疗前及治疗结束时检测血清总胆红素、非结合胆红素、凝血酶原时间及白蛋白水平。

结果

Evacure - 4A和PS - 06膜式血浆分离器均能有效清除胆红素，所有患者经血浆置换治疗后血清总胆红素、非结合胆红素水平均显著下降。A组血清总胆红素水平从（464.2±193.8）μmol/L降至（279.4±158.7）μmol/L，非结合胆红素水平从（293.5±129.1）μmol/L降至（175.5±106.7）μmol/L（t = 5.45，10.36，P < 0.01）。B组血清总胆红素水平从（493.2±126.9）μmol/L降至（299.7±96.5）μmol/L，非结合胆红素水平从（300.2±74.3）μmol/L降至（171.5±53.1）μmol/L（t = 5.17，12.04，P < 0.01）。A、B两组经血浆置换治疗后血清白蛋白水平均升高，与PS - 06相比，采用Evacure - 4A膜式血浆分离器进行血浆置换治疗的患者白蛋白升高百分比更高[（8.3±0.7）%对（3.4±9.3）%，t = 2.76，P < 0.01]。