Zhang Da-zhi, Zhao You-rong, Zhang Quan-hai, Wang Zhi-yi, Qin Bo, He Hua, Zhou Zhi, Guo Shu-hua
The Institute for Viral Hepatitis, Chongqing Medical University, Chongqing 400010, China.
Zhonghua Gan Zang Bing Za Zhi. 2004 Apr;12(4):208-9.
In order to compare the efficacy of two kinds of membrane plasma separator on the treatment of patients with severe hepatitis B.
63 cases suffering from chronic severe hepatitis B were divided into two groups, 25 cases were treated with plasma exchange using Evacure-4A membrane plasma separator (A group) or 38 cases were using PS-06 membrane plasma separator (B group). Both of them also were treated with similar basic medical treatment. The level of serum total bilirubin, non-conjugated bilirubin, prothrombin time and albumin were tested at baseline and the end of the treatment with PE.
Evacure-4A and PS-06 membrane plasma separators can effientively remove bilirubin, the levels of serum total bilirubin, non-conjugated bilirubin of all patients were significantly decreased after treated with PE. In A group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (464.2+/-193.8)micromol/L to (279.4+/-158.7)micromol/L, (293.5+/-129.1)micromol/L to (175.5+/-106.7)micromol/L (t=5.45, 10.36, P<0.01) respectively. In B group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (493.2+/-126.9)micromol/L to (299.7+/-96.5)micromol/L, (300.2+/-74.3)micromol/L to (171.5+/-53.1)micromol/L (t=5.17, 12.04, P<0.01) respectively. The level of serum albumin increased after treated with PE in A and B groups, to contrast with PS-06, the increasing percentage of albumin was higher when the patients were treated with PE using Evacure-4A membrane plasma separator [(8.3+/-0.7) % vs. (3.4+/-9.3) %, t = 2.76, P<0.01].
Evacure-4A membrane plasma separator may be better than PS-06 membrane plasma separator on the treatment of patients with chronic severe hepatitis B.
比较两种膜式血浆分离器治疗重型乙型肝炎患者的疗效。
将63例慢性重型乙型肝炎患者分为两组，25例采用Evacure - 4A膜式血浆分离器进行血浆置换治疗（A组），38例采用PS - 06膜式血浆分离器进行血浆置换治疗（B组）。两组均给予相似的基础内科治疗。在血浆置换治疗前及治疗结束时检测血清总胆红素、非结合胆红素、凝血酶原时间及白蛋白水平。
Evacure - 4A和PS - 06膜式血浆分离器均能有效清除胆红素，所有患者经血浆置换治疗后血清总胆红素、非结合胆红素水平均显著下降。A组血清总胆红素水平从（464.2±193.8）μmol/L降至（279.4±158.7）μmol/L，非结合胆红素水平从（293.5±129.1）μmol/L降至（175.5±106.7）μmol/L（t = 5.45，10.36，P < 0.01）。B组血清总胆红素水平从（493.2±126.9）μmol/L降至（299.7±96.5）μmol/L，非结合胆红素水平从（300.2±74.3）μmol/L降至（171.5±53.1）μmol/L（t = 5.17，12.04，P < 0.01）。A、B两组经血浆置换治疗后血清白蛋白水平均升高，与PS - 06相比，采用Evacure - 4A膜式血浆分离器进行血浆置换治疗的患者白蛋白升高百分比更高[（8.3±0.7）%对（3.4±9.3）%，t = 2.76，P < 0.01]。
在治疗慢性重型乙型肝炎患者方面，Evacure - 4A膜式血浆分离器可能优于PS - 06膜式血浆分离器。
