Gan Lu, Hua Zhang Sheng, Liang Yang Xiang, Bi Xu Hui
Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China.
Int Immunopharmacol. 2004 Apr;4(4):563-9. doi: 10.1016/j.intimp.2004.01.023.
The modulation of a polysaccharide-protein complex from Lycium barbarum (LBP3p) on the immune system in S180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with LBP3p (5, 10 and 20 mg/kg) for 10 days. The effects of LBP3p on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS), lymphocyte proliferation, the activity of cytotoxic T lymphocyte (CTL), interleukin-2 (IL-2) gene expression and lipid peroxidation were studied. LBP3p could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, CTL activity, IL-2 mRNA expression level and reduce the lipid peroxidation in S180-bearing mice. The effect is not dose-dependent in a linear fashion. A total of 10 mg/kg dose is more effective than 5 and 20 mg/kg doses. This suggests that LBP3p at 10 mg/kg has a highly significant effect on tumor weight and improves the immune system.
研究了枸杞多糖蛋白复合物（LBP3p）对荷S180小鼠免疫系统的调节作用。接种S180细胞悬液的小鼠经口给予LBP3p（5、10和20 mg/kg），持续10天。研究了LBP3p对可移植肿瘤、巨噬细胞吞噬作用、绵羊红细胞定量溶血（QHS）、淋巴细胞增殖、细胞毒性T淋巴细胞（CTL）活性、白细胞介素-2（IL-2）基因表达和脂质过氧化的影响。LBP3p可显著抑制荷S180小鼠可移植肉瘤S180的生长，增强巨噬细胞吞噬作用、脾细胞分泌抗体的形式、脾淋巴细胞增殖、CTL活性、IL-2 mRNA表达水平，并降低脂质过氧化。其作用并非呈线性剂量依赖性。10 mg/kg剂量比5和20 mg/kg剂量更有效。这表明10 mg/kg的LBP3p对肿瘤重量有高度显著影响，并能改善免疫系统。
