Forster C, Magerl W, Beck A, Geisslinger G, Gall T, Brune K, Handwerker H O
Institute of Physiology and Biokybernetics, University of Erlangen, Germany.
Agents Actions. 1992 Jan;35(1-2):112-21. doi: 10.1007/BF01990960.
In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain. To this purpose interdigital webs were pinched repeatedly for 2 min periods. The painfulness of these stimuli was assessed by the subjects on an electronically controlled visual analogue scale at 10 sec intervals. In addition to the subjective pain ratings the stimulus induced reflex diminution of the blood flow in the stimulated hand was measured with photoplethysmography and laser Doppler flow analysis. The flare response around the stimulated area was assessed with infrared thermography. In this assay system ibuprofen and dipyrone, but not paracetamol, showed statistically significant analgesic effects by preventing hyperalgesia which is normally induced by the repeated stimulation of a skin site. This hypoalgesic effect was not related to the subjective impression of the subjects of the analgesic potency of the respective drug. Sympathetic reflex vasoconstriction was not quantitatively related to the drug induced hypoalgesia. Ibuprofen and, to a minor extent, the other antipyretic analgesic drugs also diminished the stimulus induced flare reaction around the stimulated skin sites.
在一项针对22名健康受试者的双盲交叉研究中，使用实验性诱导疼痛模型，以安慰剂为对照，测试了解热镇痛药布洛芬、安乃近和对乙酰氨基酚的镇痛效果。为此，反复捏指间蹼2分钟。受试者每隔10秒通过电子控制的视觉模拟量表评估这些刺激的疼痛程度。除了主观疼痛评分外，还用光电容积描记法和激光多普勒血流分析测量刺激引起的受刺激手部血流反射性减少。用红外热成像评估刺激区域周围的红斑反应。在该检测系统中，布洛芬和安乃近，而非对乙酰氨基酚，通过预防通常由反复刺激皮肤部位诱发的痛觉过敏，显示出具有统计学意义的镇痛效果。这种痛觉减退效应与受试者对相应药物镇痛效力的主观印象无关。交感反射性血管收缩与药物诱导的痛觉减退在数量上没有关系。布洛芬以及在较小程度上其他解热镇痛药也减轻了刺激引起的受刺激皮肤部位周围的红斑反应。
