Berraquero R, Palacios J, Rodríguez J I
Department of Pathology, La Paz Hospital, Madrid, Spain.
Am J Orthod Dentofacial Orthop. 1992 Sep;102(3):220-6. doi: 10.1016/S0889-5406(05)81056-X.
A new approach to evaluate the role of the condyle in mandibular growth could be its study in chondrodysplasias. The growth of the condylar cartilage and the mandible has not previously been reported in thanatophoric dysplasia (TD), a lethal osteochondrodysplasia. We have studied the light microscopic, histomorphometric, and radiologic findings in four infants affected by TD and in four control infants. The diagnosis was made on the basis of clinical, radiographic, and pathologic criteria. All the measured radiographic parameters of the patients' mandibles showed a normal longitudinal growth in TD, despite the severe disturbance of the condylar cartilages. The lesions in the chondroblastic cells and the extracellular matrix were similar to those observed in growth plate cartilages in TD. Marked membranous ossification spread from the cartilage canals of the condyles. The articular and prechondroblastic layers were histologically normal. Histomorphometry demonstrated that condylar cartilages were twice as thick as normal in TD, mainly because of the thickening by the chondroblastic layer. Present results support the hypothesis that condylar cartilage is a secondary growth site instead of being a primary growth center.
一种评估髁突在下颌骨生长中作用的新方法可能是对软骨发育异常中的髁突进行研究。致死性骨软骨发育异常——致死性侏儒症（TD）中髁突软骨和下颌骨的生长情况此前尚未见报道。我们研究了4例患TD的婴儿和4例对照婴儿的光镜、组织形态计量学及放射学表现。诊断基于临床、影像学和病理学标准。尽管髁突软骨严重受损，但患者下颌骨所有测量的影像学参数在TD中均显示纵向生长正常。成软骨细胞和细胞外基质中的病变与TD生长板软骨中观察到的病变相似。明显的膜内成骨从髁突的软骨管扩散。关节层和软骨前层在组织学上正常。组织形态计量学表明，TD中髁突软骨厚度是正常的两倍，主要是由于成软骨细胞层增厚。目前的结果支持这样的假说，即髁突软骨是一个继发性生长部位而非原发性生长中心。
